We suggest that the exciting developments in technology that are beginning to enable precise and convenient measures of individuals’ physical and physiological states can be combined with our knowledge of how the brain processes these physical and physiological signals in order to generate new insights into how negative emotions and mental distress can be represented and controlled. Crucially, the exquisite skills of games designers in creating compelling worlds and narratives offer optimal contexts within which individuals can experience and learn about these body-brain interactions, developing the skills to recognise and control them and, as a consequence, to profoundly change their experiences for the better. Individually-sensitive and responsive game mechanics will offer unique and enjoyable personalised training that can be generalised to the everyday world with a consequent improvement in mental well-being.